diff --git a/cpu/cc26x0/cpu.c b/cpu/cc26x0/cpu.c
index a998cca23..2f4f55ecd 100644
--- a/cpu/cc26x0/cpu.c
+++ b/cpu/cc26x0/cpu.c
@@ -17,7 +17,20 @@
  * @}
  */
 
-#include "cpu.h"
+ #include "cpu.h"
+ #include "periph_conf.h"
+
+#ifndef HF_CLOCK_SOURCE
+#define HF_CLOCK_SOURCE DDI_0_OSC_CTL0_SCLK_HF_SRC_SEL_RCOSC /* set 48MHz RCOSC */
+#endif
+#ifndef LF_CLOCK_SOURCE
+#define LF_CLOCK_SOURCE DDI_0_OSC_CTL0_SCLK_LF_SRC_SEL_HF_RCOSC /* set 31.25kHz derived from 48MHz RCOSC */
+#endif
+
+/**
+ *@brief Configure the MCU system clock
+ */
+static void cpu_clock_init(void);
 
 /**
  * @brief Initialize the CPU, set IRQ priorities
@@ -26,4 +39,16 @@ void cpu_init(void)
 {
     /* initialize the Cortex-M core */
     cortexm_init();
+
+    /* initialize the system clock */
+    cpu_clock_init();
+}
+
+static void cpu_clock_init(void)
+{
+    AON_WUC->AUXCTL |= AUXCTL_AUX_FORCE_ON; /* power on AUX_PD */
+    while(!(AON_WUC->PWRSTAT & PWRSTAT_AUX_PD_ON)); /* wait for AUX_PD to be powered on */
+    AUX_WUC->MODCLKEN0 |= MODCLKEN0_AUX_DDI0_OSC_EN; /* turn on oscillator interface clock */
+
+    DDI_0_OSC->CTL0 |= HF_CLOCK_SOURCE | LF_CLOCK_SOURCE; /* configure HF and LF clocks */
 }
diff --git a/cpu/cc26x0/include/cc26x0_aux.h b/cpu/cc26x0/include/cc26x0_aux.h
index 52d3293a8..a790bb63d 100644
--- a/cpu/cc26x0/include/cc26x0_aux.h
+++ b/cpu/cc26x0/include/cc26x0_aux.h
@@ -136,6 +136,14 @@ typedef struct {
  * @brief   AUX_WUC register values
  * @{
  */
+#define MODCLKEN0_SMPH_EN           0x00000001  /* enable clock for AUX_SMPH */
+#define MODCLKEN0_AIODIO0_EN        0x00000002  /* enable clock for AUX_AIODIO0 */
+#define MODCLKEN0_AIODIO1_EN        0x00000004  /* enable clock for AUX_AIODIO1 */
+#define MODCLKEN0_TIMER_EN          0x00000008  /* enable clock for AUX_TIMER */
+#define MODCLKEN0_ANAIF_EN          0x00000010  /* enable clock for AUX_ANAIF */
+#define MODCLKEN0_TDC_EN            0x00000020  /* enable clock for AUX_TDC */
+#define MODCLKEN0_AUX_DDI0_OSC_EN   0x00000040  /* enable clock for AUX_DDI0_OSC */
+#define MODCLKEN0_AUX_ADI4_EN       0x00000080  /* enable clock for AUX_ADI4 */
 /** @} */
 
 /** @ingroup cpu_specific_peripheral_memory_map